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27 Medical conditions in which heavy metal ion excess promotes oxidative stress include iron overload (hemochromatosis or hemosiderosis), copper overload (Wilsons disease), and heavy metal poisoning (Hg, Pb, Ni, Se, etc.)

After oral administration for 7 days with the last dose given 1 hour before the experiment, all mice were placed in a hypoxic chamber with an O 2 concentration of 8% and observed for survival rate within 15 min ( 2.4 Rat high-altitude hypoxia model and drug administration Four groups were formed by randomly assigning twenty-four male SD rats: normoxia control group (NC, physiological saline, 1 mL/100 g), hypobaric hypoxia model group (HH, physiological saline, 1 mL/100 g), ginsenosides group (GS, 100 mg/kg), and Salidroside group (Sal, 100 mg/kg)